Rabbit Syndecan-1 Protein 5100

$375.00 – $1,250.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Leu23-Gly254

SKU: 5100parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	XP_008252990
express system	HEK293
product tag	C-His
purity	> 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans. CD138 is significant for cell-cell and cell-matrix interactions.CD138 plays a crucial role in carcinogenesis and is an attractive target for anticancer treatment with heparanase inhibitors and anti-CD138 antibodies for immunotherapy.
molecular weight	The protein has a predicted MW of 24.57 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Rabbit Syndecan-1 Protein 5100

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CD138 (syndecan-1, Sdc-1) is a member of the syndecan family that comprises heparan sulfate proteoglycans. CD138 is significant for cell-cell and cell-matrix interactions.CD138 plays a crucial role in carcinogenesis and is an attractive target for anticancer treatment with heparanase inhibitors and anti-CD138 antibodies for immunotherapy.
Protein names Syndecan-1 (SYND1) (CD antigen CD138)
Protein family Syndecan proteoglycan family
Mass 32462Da
Function Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250\|UniProtKB:P18828, ECO:0000269\|PubMed:22660413}.
Subellular location Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269\|PubMed:9169435}. Secreted, extracellular exosome {ECO:0000269\|PubMed:22660413}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269\|PubMed:9169435}.
Tissues Detected in placenta (at protein level) (PubMed:32337544). Detected in fibroblasts (at protein level) (PubMed:36213313). {ECO:0000269\|PubMed:32337544, ECO:0000269\|PubMed:36213313}.
Structure Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain). Interacts with MDK (By similarity). {ECO:0000250\|UniProtKB:P26260, ECO:0000269\|PubMed:16007225, ECO:0000269\|PubMed:23395182}.
Post-translational modification Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. {ECO:0000269\|PubMed:9169435}.
Target Relevance information above includes information from UniProt accession: P18827
The UniProt Consortium

Data

The purity of Rabbit Syndecan-1 is greater than 90% as determined by SEC-HPLC.

SDS-PAGE gel of Rabbit Syndecan-1 Protein

Rabbit Syndecan-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.