Mouse Semaphorin 4D/SEMA4D/CD100 Protein 3168

$300.00 – $1,000.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Phe24-Arg733

SKU: 3168parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	O09126
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Semaphorin 4D (Sema4D) is a multifunctional protein widely expressed in an organism that plays an important role in the control of many physiological and pathological processes, including immunoregulation, neurogenesis, angiogenesis, and tumor progression.
molecular weight	The protein has a predicted MW of 79.87 kDa. Due to glycosylation, the protein migrates to 100-130 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse Semaphorin 4D/SEMA4D/CD100 Protein 3168

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Semaphorin 4D (Sema4D) is a multifunctional protein widely expressed in an organism that plays an important role in the control of many physiological and pathological processes, including immunoregulation, neurogenesis, angiogenesis, and tumor progression.
Protein names Semaphorin-4D (M-Sema G) (Semaphorin-C-like 2) (Semaphorin-J) (Sema J) (CD antigen CD100)
Gene names Sema4d,Sema4d Semacl2 Semaj
Protein family Semaphorin family
Mass 10090Da
Function Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (PubMed:23699507, PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (PubMed:23699507, PubMed:29981480). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). Promotes the migration of cerebellar granule cells (PubMed:17554007). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (By similarity). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (By similarity).
Subellular location Cell membrane ; Single-pass type I membrane protein .
Tissues Strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues (PubMed:8969198). Expressed in neurons and glia in the developing hippocampus (PubMed:29981480).
Structure Homodimer (By similarity). Interacts with PLXNB1 (By similarity). Interacts with PLXNB2 (PubMed:17554007).
Target Relevance information above includes information from UniProt accession: O09126
The UniProt Consortium

Data

HPLC of Mouse Semaphorin 4D/SEMA4D/CD100 Protein

The purity of Mouse Semaphorin 4D is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse Semaphorin 4D/SEMA4D/CD100 Protein

Mouse Semaphorin 4D on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.