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Mouse PD-L2/B7-DC Protein 2503

$240.00$800.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Leu20-Trp221
SKU: 2503parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q9WUL5

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.

molecular weight

The protein has a predicted MW of 23.92 kDa. Due to glycosylation, the protein migrates to 40-60 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse PD-L2/B7-DC Protein 2503

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
Protein names
Programmed cell death 1 ligand 2 (PD-1 ligand 2) (PD-L2) (PDCD1 ligand 2) (Programmed death ligand 2) (Butyrophilin B7-DC) (B7-DC) (CD antigen CD273)
Gene names
Pdcd1lg2,Pdcd1lg2 B7dc Btdc Cd273 Pdl2
Protein family
Immunoglobulin superfamily, BTN/MOG family
Mass
10090Da
Function
Involved in the costimulatory signal essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
Subellular location
Cell membrane ; Single-pass type I membrane protein .
Tissues
Expressed in immature and mature bone marrow-derived dendritic cells and splenic dendritic cells. Highly expressed in placenta, liver and weakly expressed in heart, spleen, lymph nodes and thymus. Also expressed in some tumor cell lines of lymphoid origin.
Structure
Interacts with PDCD1.
Target Relevance information above includes information from UniProt accession: Q9WUL5
The UniProt Consortium

ELISA with Mouse PD-L2/B7-DC Protein
Immobilized Mouse PD-L2, His Tag at 5µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human PD-1, hFc Tag with the EC50 of 0.32µg/ml determined by ELISA.
HPLC of Mouse PD-L2/B7-DC Protein
The purity of Mouse PD-L2 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse PD-L2/B7-DC Protein
Mouse PD-L2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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