Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P97466 |
express system | HEK293 |
product tag | C-hFc |
purity | > 90% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
background | Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β‑catenin, EGFR, ERK and Akt. |
molecular weight | The protein has a predicted MW of 49.83 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse Noggin Protein 2401
$270.00 – $900.00
Summary
- Expression: HEK293
- Active: Yes (cell based assay)
- Amino Acid Range: Gln28-Cys232
Mouse Noggin Protein 2401
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Noggin is an antagonist of bone morphogenetic proteins (BMP), being indispensable for certain developmental events.Noggin expression positively correlated with EGFR expression in both GC cell line models and The Cancer Genome Atlas human GC cohort. Targeting EGFR and its downstream pathways diminished cell proliferation which was promoted by Noggin. Noggin promotes the proliferation of GC cells by upregulating EGFR and enhancing a vicious circle formed by β-catenin, EGFR, ERK and Akt. |
Protein names Noggin |
Gene names Nog,Nog |
Protein family Noggin family |
Mass 10090Da |
Function Essential for cartilage morphogenesis and joint formation. Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite (PubMed:9585504, PubMed:9603738). Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6 (By similarity). |
Subellular location Secreted. |
Tissues Expressed in condensing cartilage and immature chondrocytes. |
Structure Homodimer. Interacts with GDF5; inhibits chondrocyte differentiation. |
Target Relevance information above includes information from UniProt accession: P97466 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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