Mouse LTBR Protein 3834

$150.00 – $500.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gln31-Leu223

SKU: 3834parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P50284
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB.TRAF3 functions as a negative regulator of LTBR signaling via both canonical and non-canonical NFkappaB pathways by two distinct mechanisms. These effects of TRAF3 depletion did not require LTBR signaling and were consistent with autonomous activation of the non-canonical NFkappaB pathway.
molecular weight	The protein has a predicted MW of 48.5 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse LTBR Protein 3834

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Components of lymphotoxin beta receptor (LTBR)-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB.TRAF3 functions as a negative regulator of LTBR signaling via both canonical and non-canonical NFkappaB pathways by two distinct mechanisms. These effects of TRAF3 depletion did not require LTBR signaling and were consistent with autonomous activation of the non-canonical NFkappaB pathway.
Protein names Tumor necrosis factor receptor superfamily member 3 (Lymphotoxin-beta receptor)
Gene names Ltbr,Ltbr Tnfcr Tnfrsf3
Mass 44956Da
Function FUNCTION: Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Activates NF-kappa-B signaling upon stimulation with lymphotoxin. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs. {ECO:0000250, ECO:0000250\|UniProtKB:P36941}.; FUNCTION: (Microbial infection) Plays a role in host defense against Zika virus infection. {ECO:0000269\|PubMed:29507355}.
Subellular location SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Structure SUBUNIT: Self-associates; dimerization and trimerization are promoted by lymphotoxin (LTA(3)) (PubMed:29507355). Associates with TRAF3 (By similarity). Associates with TRAF4 (By similarity). Associates with TRAF5 (PubMed:8663299). {ECO:0000250, ECO:0000250\|UniProtKB:P36941, ECO:0000269\|PubMed:29507355, ECO:0000269\|PubMed:8663299}.
Target Relevance information above includes information from UniProt accession: P50284
The UniProt Consortium

Data

The purity of Mouse LTBR is greater than 95% as determined by SEC-HPLC.

Mouse LTBR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.