Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q3UWA6 |
express system | HEK293 |
product tag | C-His-Avi |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. |
molecular weight | The protein has a predicted MW of 50.01 kDa. Due to glycosylation, the protein migrates to 70-120 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse GUCY2C/Guanylyl cyclase C Protein 2650
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Val20-Met433
Mouse GUCY2C/Guanylyl cyclase C Protein 2650
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. |
Protein names Guanylyl cyclase C (GC-C) (EC 4.6.1.2) (Heat-stable enterotoxin receptor) (STA receptor) (Intestinal guanylate cyclase) |
Gene names Gucy2c,Gucy2c Guc2c |
Protein family Adenylyl cyclase class-4/guanylyl cyclase family |
Mass 10090Da |
Function Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP. |
Subellular location Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum membrane ; Single-pass type I membrane protein. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form. |
Structure Homotrimer. Interacts via its C-terminal region with NHERF4. Interacts with the lectin chaperone VIP36. |
Post-translational modification Glycosylation at Asn-75 and/or Asn-79 is required for interaction with VIP36 while glycosylation at Asn-345 and Asn-402 modulates ligand-mediated GC-C activation. |
Domain Th |
Target Relevance information above includes information from UniProt accession: Q3UWA6 |
The UniProt Consortium |
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The purity of Mouse GUCY2C is greater than 95% as determined by SEC-HPLC. |
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Mouse GUCY2C on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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