Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P41272 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co‑stimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. |
molecular weight | The protein has a predicted MW of 19.40 kDa. Due to glycosylation, the protein migrates to 38-48 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Mouse CD27/TNFRSF7 Protein 2097
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Pro24-Arg182
Mouse CD27/TNFRSF7 Protein 2097
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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CD27, also known as TNFRSF7, is an approximately 55 kDa transmembrane protein in the TNF receptor superfamily. It functions as a co-stimulatory molecule that supports lymphocyte activation and survival. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. |
Protein names CD27 antigen (CD27L receptor) (T-cell activation antigen CD27) (Tumor necrosis factor receptor superfamily member 7) (CD antigen CD27) |
Gene names Cd27,Cd27 Tnfrsf7 |
Mass 10090Da |
Function Receptor specifically expressed at the surface of T cells which binds and is activated by its ligand CD70/CD27L expressed by B cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. |
Subellular location Cell membrane ; Single-pass type I membrane protein . |
Tissues In thymus and spleen, but not in non-lymphoid tissues. |
Structure Homodimer. Interacts with SIVA1; may play a role in apoptosis through association with SIVA1. Interacts with TRAF2. |
Post-translational modification Phosphorylated.; N-glycosylated.; O-glycosylated with core 1 or possibly core 8 glycans. |
Target Relevance information above includes information from UniProt accession: P41272 |
The UniProt Consortium |
Publications
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