ELISA with Mouse BAFFR/TNFRSF13C Protein 3594

Mouse BAFFR/TNFRSF13C Protein 3594

$300.00 – $1,000.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Ser10-Ala71

SKU: 3594parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q9D8D0
express system	HEK293
product tag	C-hFc
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
molecular weight	The protein has a predicted MW of 33.5 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Mouse BAFFR/TNFRSF13C Protein 3594

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
BAFF binds to three TNF receptor superfamily members: B-cell maturation antigen (BCMA/TNFRSF17), transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI/TNFRSF13B) and BAFF receptor (BAFF R/BR3/TNFRSF13C). These receptors are type III transmembrane proteins that lack a signal peptide. Whereas TACI and BCMA bind BAFF and another TNF superfamily ligand, APRIL (a proliferation-inducing ligand), BAFF R selectively binds BAFF.
Protein names Tumor necrosis factor receptor superfamily member 13C (B-cell maturation defect) (B-cell-activating factor receptor) (BAFF receptor) (BAFF-R) (BLyS receptor 3) (CD antigen CD268)
Gene names Tnfrsf13c,Tnfrsf13c Baffr Bcmd Br3
Mass 10090Da
Function B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
Subellular location Membrane ; Single-pass type III membrane protein .
Tissues Highly expressed in spleen and testis; detected at lower levels in lung and thymus.
Target Relevance information above includes information from UniProt accession: Q9D8D0
The UniProt Consortium

Data

ELISA with Mouse BAFFR/TNFRSF13C Protein

Immobilized Human BAFF (Trimer), His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Mouse BAFFR, hFc Tag with the EC50 of 18.4ng/ml determined by ELISA (QC test).

Immobilized Mouse BAFF, His Tag at 5µg/ml (100µl/Well) on the plate. Dose response curve for Mouse BAFFR, hFc Tag with the EC50 of 5.9ng/ml determined by ELISA.

The purity of Mouse BAFFR is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Mouse BAFFR/TNFRSF13C Protein

Mouse BAFFR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.