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Mouse Activin RIIA/ACVR2A Protein 2043

$150.00$500.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Ala20-Pro135
SKU: 2043parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P27038

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.

molecular weight

The protein has a predicted MW of 15.06 kDa. Due to glycosylation, the protein migrates to 35-45 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Mouse Activin RIIA/ACVR2A Protein 2043

protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Activin A receptor type 2A (ACVR2A) is a membrane receptor in the transforming growth factor- beta (TGF-β signaling pathway, which is involved in the regulation of cell proliferation, migration, and apoptosis. Loss of ACVR2A has an important role in cancer progression and distant metastasis and may serve as a prognostic marker in patients with colon cancer.
Protein names
Activin receptor type-2A (EC 2.7.11.30) (Activin receptor type IIA) (ACTR-IIA)
Gene names
Acvr2a,Acvr2a Acvr2
Protein family
Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfam
Mass
10090Da
Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555).
Catalytic activity
BINDING 198..206; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"; BINDING 219; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
Subellular location
Cell membrane ; Single-pass type I membrane protein .
Tissues
Brain, testis, intestine, liver and kidney.
Structure
Part of a complex consisting of MAGI2/ARIP1, ACVR2A, ACVR1B and SMAD3 (PubMed:10681527). Interacts with MAGI2/ARIP1 (PubMed:10681527). Interacts with type I receptor ACVR1 (By similarity). Interacts with BMP7 (By similarity). Interacts with TSC22D1/TSC-22 (By similarity).
Target Relevance information above includes information from UniProt accession: P27038
The UniProt Consortium

ELISA with Mouse Activin RIIA/ACVR2A Protein
Immobilized Human Activin A, No Tag at 5µg/ml (100µl/Well) on the plate. Dose response curve for Mouse Activin RIIA, His Tag with the EC50 of 0.13µg/ml determined by ELISA.
HPLC of Mouse Activin RIIA/ACVR2A Protein
The purity of Mouse Activin RIIA is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Mouse Activin RIIA/ACVR2A Protein
Mouse Activin RIIA on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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