Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q8TD07 |
express system | HEK293 |
product tag | C-hFc |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | UL16-binding proteins (ULBPs) are markers of cellular stress which are upregulated on the surface of virus-infected and tumor cells. ULBPs are expressed by a variety of leukemias, carcinomas, melanomas, and tumor cell lines.ULBP4 is associated with higher levels of CD8+/NKG2D+ lymphocytes infiltrating the carcinoma and is a prognosticator of improved survival. |
molecular weight | The protein has a predicted MW of 49.12 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human ULBP-4 Protein 2661
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Binding assay: Yes (SPR)
- Amino Acid Range: His31-Asp225
Human ULBP-4 Protein 2661
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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UL16-binding proteins (ULBPs) are markers of cellular stress which are upregulated on the surface of virus-infected and tumor cells. ULBPs are expressed by a variety of leukemias, carcinomas, melanomas, and tumor cell lines.ULBP4 is associated with higher levels of CD8+/NKG2D+ lymphocytes infiltrating the carcinoma and is a prognosticator of improved survival. |
Protein names Retinoic acid early transcript 1E (Lymphocyte effector toxicity activation ligand) (NKG2D ligand 4) (N2DL-4) (NKG2DL4) (RAE-1-like transcript 4) (UL16-binding protein 4) |
Gene names RAET1E,RAET1E LETAL N2DL4 ULBP4 UNQ1867/PRO4303 |
Protein family MHC class I family |
Mass 9606Da |
Function Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. |
Subellular location Membrane ; Single-pass type I membrane protein.; [Isoform 4]: Secreted. |
Tissues Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. |
Structure Binds to KLRK1/NKG2D.; (Microbial infection) Contrary to other family members, does not interact with CMV glycoprotein UL16. |
Domain MH |
Target Relevance information above includes information from UniProt accession: Q8TD07 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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