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Human TPM1 Protein 2450

$300.00$1,000.00

Summary

  • Expression: E.coli
  • Pure: Yes (HPLC)
  • Amino Acid Range: Met1-Met284
SKU: 2450parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

NP_000357.3

express system

E.coli

product tag

N-His

purity

> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC

background

Tropomyosin-1 (TPM1), a widely expressed actin-binding protein, is downregulated in many tumors and associated with cancer progression. TPM1 overexpression in RCC cell lines can induce tumor cell apoptosis via the p53-mediated mitochondrial pathway. Further studies are needed to fully elucidate the potential of TPM1 as a candidate for RCC targeted therapy in the future.

molecular weight

The protein has a predicted MW of 34.26 kDa same as Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human TPM1 Protein 2450

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Tropomyosin-1 (TPM1), a widely expressed actin-binding protein, is downregulated in many tumors and associated with cancer progression. TPM1 overexpression in RCC cell lines can induce tumor cell apoptosis via the p53-mediated mitochondrial pathway. Further studies are needed to fully elucidate the potential of TPM1 as a candidate for RCC targeted therapy in the future.
Protein names
Tropomyosin-1
Gene names
YNL079C,TPM1 YNL079C N2332
Mass
23541Da
Subellular location
Cytoplasm, cytoskeleton {ECO:0000305}.
Structure
Homodimer. {ECO:0000250}.
Domain
The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The seque
Target Relevance information above includes information from UniProt accession: P17536
The UniProt Consortium

HPLC of Human TPM1~-Protein
The purity of Human TPM1 is greater than 90% as determined by SEC-HPLC.
SDS-PAGE gel of Human TPM1~-Protein
Human TPM1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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