Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | NP_000357.3 |
express system | E.coli |
product tag | N-His |
purity | > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
background | Tropomyosin-1 (TPM1), a widely expressed actin-binding protein, is downregulated in many tumors and associated with cancer progression. TPM1 overexpression in RCC cell lines can induce tumor cell apoptosis via the p53-mediated mitochondrial pathway. Further studies are needed to fully elucidate the potential of TPM1 as a candidate for RCC targeted therapy in the future. |
molecular weight | The protein has a predicted MW of 34.26 kDa same as Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human TPM1 Protein 2450
$300.00 – $1,000.00
Summary
- Expression: E.coli
- Pure: Yes (HPLC)
- Amino Acid Range: Met1-Met284
Human TPM1 Protein 2450
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Tropomyosin-1 (TPM1), a widely expressed actin-binding protein, is downregulated in many tumors and associated with cancer progression. TPM1 overexpression in RCC cell lines can induce tumor cell apoptosis via the p53-mediated mitochondrial pathway. Further studies are needed to fully elucidate the potential of TPM1 as a candidate for RCC targeted therapy in the future. |
Protein names Tropomyosin-1 |
Gene names YNL079C,TPM1 YNL079C N2332 |
Mass 23541Da |
Subellular location Cytoplasm, cytoskeleton {ECO:0000305}. |
Structure Homodimer. {ECO:0000250}. |
Domain The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The seque |
Target Relevance information above includes information from UniProt accession: P17536 |
The UniProt Consortium |
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The purity of Human TPM1 is greater than 90% as determined by SEC-HPLC. |
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Human TPM1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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We haven't added any publications to our database yet. |
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