Skip to content

Human TNFSF15 Protein 2277

$300.00$1,000.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Leu72-Leu251
SKU: 2277parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

O95150

express system

HEK293

product tag

N-monomeric Fc

purity

> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC

background

TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2.

molecular weight

The protein has a predicted MW of 44.87 kDa. Due to glycosylation, the protein migrates to 48-60 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human TNFSF15 Protein 2277

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
TNF superfamily member 15 (TNFSF15), a cytokine largely produced by vascular endothelial cells and a specific inhibitor of the proliferation of these same cells, can inhibit VEGF-induced vascular permeability in vitro and in vivo, and that death receptor 3 (DR3), a cell surface receptor of TNFSF15, mediates TNFSF15-induced dephosphorylation of VEGFR2.
Protein names
Tumor necrosis factor ligand superfamily member 15 (TNF ligand-related molecule 1) (Vascular endothelial cell growth inhibitor) [Cleaved into: Tumor necrosis factor ligand superfamily member 15, membrane form; Tumor necrosis factor ligand superfamily member 15, secreted form]
Gene names
TNFSF15,TNFSF15 TL1 VEGI
Protein family
Tumor necrosis factor family
Mass
9606Da
Function
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Subellular location
Membrane ; Single-pass type II membrane protein .; [Tumor necrosis factor ligand superfamily member 15, secreted form]: Secreted.
Tissues
Specifically expressed in endothelial cells. Detected in monocytes, placenta, lung, liver, kidney, skeletal muscle, pancreas, spleen, prostate, small intestine and colon.
Structure
Homotrimer.
Target Relevance information above includes information from UniProt accession: O95150
The UniProt Consortium

ELISA with Human TNFSF15 Protein
Immobilized Mouse DR3, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Human TNFSF15, hFc Tag with the EC50 of 7.5ng/ml determined by ELISA (QC Test).
ELISA with Human TNFSF15 Protein
Immobilized Human TNFSF15, hFc Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Anti-TNFSF15 Antibody, hFc Tag with the EC50 of 15.5ng/ml determined by ELISA.
HPLC of Human TNFSF15 Protein
The purity of Human TNFSF15 is greater than 90% as determined by SEC-HPLC.
SDS-PAGE gel of Human TNFSF15 Protein
Human TNFSF15 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmidtitleauthorscitation
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

relevant to this product
#
Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information.

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.