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Human TIE1 Protein 2544

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Ala22-Gln759
SKU: 2544parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P35590

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

TIE1 is a cell surface protein expressed in endothelial cells. Involved in angiogenesis and lymphangiogenesis, including morphogenesis of lymphatic valves, TIE1 is important for lymphatic system functional integrity.

molecular weight

The protein has a predicted MW of 80.93 kDa. Due to glycosylation, the protein migrates to 81-100 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human TIE1 Protein 2544

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
TIE1 is a cell surface protein expressed in endothelial cells. Involved in angiogenesis and lymphangiogenesis, including morphogenesis of lymphatic valves, TIE1 is important for lymphatic system functional integrity.
Protein names
Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1)
Gene names
TIE1,TIE1 TIE
Protein family
Protein kinase superfamily, Tyr protein kinase family, Tie subfamily
Mass
9606Da
Function
Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis.
Subellular location
Cell membrane ; Single-pass type I membrane protein .
Tissues
Specifically expressed in developing vascular endothelial cells.
Structure
Heterodimer with TEK/TIE2 (PubMed:20227369). Interacts with SVEP1 (via C-terminus) (PubMed:37097004).
Post-translational modification
Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2.
Target Relevance information above includes information from UniProt accession: P35590
The UniProt Consortium

HPLC of Human TIE1 Protein
The purity of Human TIE1 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human TIE1 Protein
Human TIE1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmidtitleauthorscitation
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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