Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P35590 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | TIE1 is a cell surface protein expressed in endothelial cells. Involved in angiogenesis and lymphangiogenesis, including morphogenesis of lymphatic valves, TIE1 is important for lymphatic system functional integrity. |
molecular weight | The protein has a predicted MW of 80.93 kDa. Due to glycosylation, the protein migrates to 81-100 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human TIE1 Protein 2544
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Ala22-Gln759
Human TIE1 Protein 2544
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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TIE1 is a cell surface protein expressed in endothelial cells. Involved in angiogenesis and lymphangiogenesis, including morphogenesis of lymphatic valves, TIE1 is important for lymphatic system functional integrity. |
Protein names Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) |
Gene names TIE1,TIE1 TIE |
Protein family Protein kinase superfamily, Tyr protein kinase family, Tie subfamily |
Mass 9606Da |
Function Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. |
Subellular location Cell membrane ; Single-pass type I membrane protein . |
Tissues Specifically expressed in developing vascular endothelial cells. |
Structure Heterodimer with TEK/TIE2 (PubMed:20227369). Interacts with SVEP1 (via C-terminus) (PubMed:37097004). |
Post-translational modification Phosphorylated on tyrosine residues in response to ANGPT1, most likely by TEK/TIE2. |
Target Relevance information above includes information from UniProt accession: P35590 |
The UniProt Consortium |
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The purity of Human TIE1 is greater than 95% as determined by SEC-HPLC. |
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Human TIE1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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We haven't added any publications to our database yet. |
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