Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q8TCT1 |
express system | E.coli |
product tag | N-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | PHOSPHO1, a phosphoethanolamine/phosphocholine phosphatase, is upregulated in mineralising cells and is thought to be involved in the generation of inorganic phosphate for bone mineralisation. |
molecular weight | The protein has a predicted MW of 30.67 kDa same as Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human PHOSPHO1 Protein 2460
$300.00 – $1,000.00
Summary
- Expression: E.coli
- Pure: Yes (HPLC)
- Amino Acid Range: Met1-Cys267
Human PHOSPHO1 Protein 2460
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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PHOSPHO1, a phosphoethanolamine/phosphocholine phosphatase, is upregulated in mineralising cells and is thought to be involved in the generation of inorganic phosphate for bone mineralisation. |
Protein names Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75) |
Gene names PHOSPHO1,PHOSPHO1 |
Protein family HAD-like hydrolase superfamily, PHOSPHO family |
Mass 9606Da |
Function Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005). Involved in the generation of inorganic phosphate for bone mineralization (By similarity). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). |
Subellular location Extracellular vesicle. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. |
Tissues Expressed at sites of mineralization in bone and cartilage. Highly expressed in osteoblast cell line SaOS-2 which produces a mineralized matrix, but not in MG-63 cell line, which do not mineralize. |
Target Relevance information above includes information from UniProt accession: Q8TCT1 |
The UniProt Consortium |
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The purity of Human PHOSPHO1 is greater than 95% as determined by SEC-HPLC. |
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Human PHOSPHO1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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We haven't added any publications to our database yet. |
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