SPR with Human OX40/TNFRSF4/CD134 Protein 4540

Human OX40/TNFRSF4/CD134 Protein 4540

$360.00 – $1,200.00

Summary

Expression: HEK293
Binding assay: Yes (SPR)
Amino Acid Range: Leu29-Ala216

SKU: 4540parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P43489
express system	HEK293
product tag	C-His-Avi
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation.
molecular weight	The protein has a predicted MW of 23.2 kDa. Due to glycosylation, the protein migrates to 48-55 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human OX40/TNFRSF4/CD134 Protein 4540

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation.
Protein names Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134)
Gene names TNFRSF4,TNFRSF4 TXGP1L
Mass 9606Da
Function Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.; (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Subellular location Membrane; Single-pass type I membrane protein.
Structure Interacts with TRAF2, TRAF3 and TRAF5.; (Microbial infection) Interacts with Human herpesvirus 6B/HHV-6B gQ1:gQ2 proteins.
Target Relevance information above includes information from UniProt accession: P43489
The UniProt Consortium

Data

SPR with Human OX40/TNFRSF4/CD134 Protein

Human OX40, His-Avi Tag captured on CM5 Chip via Anti-His Antibody can bind Human OX40 Ligand, hFc Tag with an affinity constant of 4.17 nM as determined in SPR assay (Biacore T200).

HPLC of Human OX40/TNFRSF4/CD134 Protein

The purity of Human OX40 is greater than 95% as determined by SEC HPLC.

SDS-PAGE gel of Human OX40/TNFRSF4/CD134 Protein

Human OX40 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.