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Human OX40/TNFRSF4/CD134 Protein 4540

$360.00$1,200.00

Summary

  • Expression: HEK293
  • Binding assay: Yes (SPR)
  • Amino Acid Range: Leu29-Ala216
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P43489

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation.

molecular weight

The protein has a predicted MW of 23.2 kDa. Due to glycosylation, the protein migrates to 48-55 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human OX40/TNFRSF4/CD134 Protein 4540

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation.
Protein names
Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134)
Gene names
TNFRSF4,TNFRSF4 TXGP1L
Mass
9606Da
Function
FUNCTION: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. {ECO:0000269|PubMed:7704935}.; FUNCTION: (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. {ECO:0000269|PubMed:23674671}.
Subellular location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Structure
SUBUNIT: Interacts with TRAF2, TRAF3 and TRAF5. {ECO:0000269|PubMed:16905106, ECO:0000269|PubMed:9418902, ECO:0000269|PubMed:9488716}.; SUBUNIT: (Microbial infection) Interacts with Human herpesvirus 6B/HHV-6B gQ1:gQ2 proteins. {ECO:0000269|PubMed:23674671}.
Target Relevance information above includes information from UniProt accession : P43489
The UniProt Consortium

Data

SPR with Human OX40/TNFRSF4/CD134 Protein
Human OX40, His-Avi Tag captured on CM5 Chip via Anti-His Antibody can bind Human OX40 Ligand, hFc Tag with an affinity constant of 4.17 nM as determined in SPR assay (Biacore T200).
HPLC of Human OX40/TNFRSF4/CD134 Protein
The purity of Human OX40 is greater than 95% as determined by SEC HPLC.
SDS-PAGE gel of Human OX40/TNFRSF4/CD134 Protein
Human OX40 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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