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Human OX40/TNFRSF4/CD134 Protein 4451

$225.00$750.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Leu29-Ala216
SKU: 4451parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P43489

express system

HEK293

product tag

C-hFc

purity

> 95% as determined by Tris-Bis PAGE

background

Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation.

molecular weight

The protein has a predicted MW of 46.8 kDa. Due to glycosylation, the protein migrates to 70-78 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human OX40/TNFRSF4/CD134 Protein 4451

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Tumor necrosis factor receptor superfamily, member 4 (TNFRSF4), also known as CD134 and OX40 receptor. OX40 is a secondary co-stimulatory immune checkpoint molecule, expressed after 24 to 72 hours following activation; its ligand, OX40L, is also not expressed on resting antigen presenting cells, but is following their activation.
Protein names
Tumor necrosis factor receptor superfamily member 4 (ACT35 antigen) (OX40L receptor) (TAX transcriptionally-activated glycoprotein 1 receptor) (CD antigen CD134)
Gene names
TNFRSF4,TNFRSF4 TXGP1L
Mass
9606Da
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.; (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
Subellular location
Membrane; Single-pass type I membrane protein.
Structure
Interacts with TRAF2, TRAF3 and TRAF5.; (Microbial infection) Interacts with Human herpesvirus 6B/HHV-6B gQ1:gQ2 proteins.
Target Relevance information above includes information from UniProt accession: P43489
The UniProt Consortium

Data

ELISA with Human OX40/TNFRSF4/CD134 Protein
Immobilized Human OX40 Ligand Trimer, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human OX40, hFc Tag with the EC50 of 37.7ng/ml determined by ELISA.
SDS-PAGE gel of Human OX40/TNFRSF4/CD134 Protein
Human OX40 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

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Documents

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