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Human OX40 Ligand/TNFSF4 Trimer Protein 4452

$300.00$1,000.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gln51-Leu183
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P23510

express system

HEK293

product tag

N-His-Flag

purity

> 90% as determined by Tris-Bis PAGE

background

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), which belongs to the tumor necrosis factor family. It is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.

molecular weight

The protein has a predicted MW of 49.7 kDa. Due to glycosylation, the protein migrates to 65-140 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human OX40 Ligand/TNFSF4 Trimer Protein 4452

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L),which belongs to the tumor necrosis factor family. It is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation.
Protein names
Tumor necrosis factor ligand superfamily member 4 (Glycoprotein Gp34) (OX40 ligand) (OX40L) (TAX transcriptionally-activated glycoprotein 1) (CD antigen CD252)
Gene names
TNFSF4,TNFSF4 TXGP1
Protein family
Tumor necrosis factor family
Mass
9606Da
Function
FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Subellular location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
Structure
SUBUNIT: Homotrimer. {ECO:0000269|PubMed:16905106}.
Target Relevance information above includes information from UniProt accession : P23510
The UniProt Consortium

Data

ELISA with Human OX40 Ligand/TNFSF4 Trimer Protein
Immobilized Human OX40 Ligand Trimer, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human OX40, hFc Tag with the EC50 of 37.7ng/ml determined by ELISA.
SDS-PAGE gel of Human OX40 Ligand/TNFSF4 Trimer Protein
Human OX40 Ligand Trimer on Tris-Bis PAGE under Non reducing (N) condition. The purity is greater than 90%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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