Human OGN/Osteoglycin Protein 5028

$315.00 – $1,050.00

Summary

Expression: HEK293
Pure: Yes (SDS-PAGE)
Amino Acid Range: Pro21-Phe298

SKU: 5028parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	P20774
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE
background	Osteoglycin (OGN, a.k.a. mimecan) belongs to cluster III of the small leucine-rich proteoglycans (SLRP) of the extracellular matrix (ECM). In vertebrates OGN is a characteristic ECM protein of bone. The function of OGN has mainly been studied in mammals in which it regulates collagen fibrillogenesis, the efficiency of which is increased when it is processed by BMP-1/Tolloid-like metalloproteinases. OGN has a role in wound healing in the cornea, in atherosclerotic lesions and modulates myocardial integrity and remodelling. In addition, OGN enhances the neurite outgrowth promoted by insulin-like growth factor-2 and IGF binding protein-2.
molecular weight	The protein has a predicted MW of 32.83 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human OGN/Osteoglycin Protein 5028

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Osteoglycin (OGN, a.k.a. mimecan) belongs to cluster III of the small leucine-rich proteoglycans (SLRP) of the extracellular matrix (ECM). In vertebrates OGN is a characteristic ECM protein of bone. The function of OGN has mainly been studied in mammals in which it regulates collagen fibrillogenesis, the efficiency of which is increased when it is processed by BMP-1/Tolloid-like metalloproteinases. OGN has a role in wound healing in the cornea, in atherosclerotic lesions and modulates myocardial integrity and remodelling. In addition, OGN enhances the neurite outgrowth promoted by insulin-like growth factor-2 and IGF binding protein-2.
Protein names Mimecan (Osteoglycin) (Osteoinductive factor) (OIF)
Gene names OGN,OGN OIF SLRR3A
Protein family Small leucine-rich proteoglycan (SLRP) family, SLRP class III subfamily
Mass 9606Da
Function Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.
Subellular location Secreted, extracellular space, extracellular matrix .
Tissues Bone.
Post-translational modification O-glycosylated with a core 1 or possibly core 8 glycan.; Contains keratan sulfate.
Target Relevance information above includes information from UniProt accession: P20774
The UniProt Consortium

Data

SDS-PAGE gel of Human OGN/Osteoglycin Protein

Human OGN on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.