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Human NKp46/NCR1/CD335 Protein 4861

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gln22-Asn255
SKU: 4861parent Categories: , Tags: , , ,
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

O76036

express system

HEK293

product tag

C-mFc

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.

molecular weight

The protein has a predicted MW of 52.9 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human NKp46/NCR1/CD335 Protein 4861

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells.
Protein names
Natural cytotoxicity triggering receptor 1 (Lymphocyte antigen 94 homolog) (NK cell-activating receptor) (Natural killer cell p46-related protein) (NK-p46) (NKp46) (hNKp46) (CD antigen CD335)
Gene names
NCR1,NCR1 LY94
Protein family
Natural cytotoxicity receptor (NCR) family
Mass
9606Da
Function
FUNCTION: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. {ECO:0000269|PubMed:9730896}.
Subellular location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissues
TISSUE SPECIFICITY: Selectively expressed by both resting and activated NK cells. {ECO:0000269|PubMed:9730896}.
Structure
SUBUNIT: Interacts with CD247 and FCER1G. {ECO:0000269|PubMed:9730896}.
Post-translational modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9730896}.; PTM: O-glycosylated. {ECO:0000269|PubMed:9730896}.
Target Relevance information above includes information from UniProt accession : O76036
The UniProt Consortium

Data

ELISA with Human NKp46/NCR1/CD335 Protein
Immobilized Human NKp46, mFc Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-Nkp46 Antibody, hFc Tag with the EC50 of 30.9ng/ml determined by ELISA.
HPLC of Human NKp46/NCR1/CD335 Protein
The purity of Human NKp46 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human NKp46/NCR1/CD335 Protein
Human NKp46 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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