Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | O76036 |
express system | HEK293 |
product tag | C-mFc |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. |
molecular weight | The protein has a predicted MW of 52.9 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human NKp46/NCR1/CD335 Protein 4861
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Gln22-Asn255
Human NKp46/NCR1/CD335 Protein 4861
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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NKp46, along with NKp30 and NKp44, are activating receptors that have been collectively termed the natural cytotoxicity receptors (NCR).These receptors lack significant sequence homology to one another. They are expressed almost exclusively by NK cells and play a major role in triggering some of the key lytic activities of NK cells. |
Protein names Natural cytotoxicity triggering receptor 1 (Lymphocyte antigen 94 homolog) (NK cell-activating receptor) (Natural killer cell p46-related protein) (NK-p46) (NKp46) (hNKp46) (CD antigen CD335) |
Gene names NCR1,NCR1 LY94 |
Protein family Natural cytotoxicity receptor (NCR) family |
Mass 9606Da |
Function Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. |
Subellular location Cell membrane ; Single-pass type I membrane protein . |
Tissues Selectively expressed by both resting and activated NK cells. |
Structure Interacts with CD247 and FCER1G. |
Post-translational modification N-glycosylated.; O-glycosylated. |
Target Relevance information above includes information from UniProt accession: O76036 |
The UniProt Consortium |
Data
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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Documents
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