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Human NKp30/NCR3/CD337 Protein 4658

$240.00$800.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Leu19-Thr138
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

AAH52582

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

NKp30, along with NKp44 and NKp46, constitute a group of receptors termed "Natural Cytotoxicity Receptors". These receptors play a major role in triggering NK-mediated killing of most tumor cells lines.NKp30 stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

molecular weight

The protein has a predicted MW of 20 kDa. Due to glycosylation, the protein migrates to 26-40 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human NKp30/NCR3/CD337 Protein 4658

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
No information
target relevance

Data

SPR with Human NKp30/NCR3/CD337 Protein
Human B7-H6, hFc Tag captured on CM5 Chip via Protein A can bind Human NKp30, His Tag with an affinity constant of 0.292 µM as determined in SPR assay (Biacore T200).
ELISA with Human NKp30/NCR3/CD337 Protein
Immobilized Human NKp30, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Human B7-H6, hFc Tag with the EC50 of 55.9ng/ml determined by ELISA (QC Test).
ELISA with Human NKp30/NCR3/CD337 Protein
Immobilized Human NKp30, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-NKp30 Antibody, hFc Tag with the EC50 of 2.4ng/ml determined by ELISA.
HPLC of Human NKp30/NCR3/CD337 Protein
The purity of Human NKp30 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human NKp30/NCR3/CD337 Protein
Human NKp30 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

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