Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q03426 |
express system | Baculovirus-Insect Cells |
product tag | N-His-GST, C-Strep-II |
purity | > 90% as determined by Tris-Bis PAGE |
background | Mevalonate kinase (MK) is an essential enzyme in the mevalonate pathway which produces numerous cellular isoprenoids. The enzyme has been characterized both at the biochemical and the molecular level in a variety of organisms. Despite the fact that mevalonate kinase is not the rate-limiting enzyme in isoprenoid biosynthesis, its activity is subject to feedback regulation by the branch-point intermediates geranyldiphosphate, farnesyldiphosphate and geranylgeranyldiphosphate. |
molecular weight | The protein has a predicted MW of 72.23 kDa. The protein migrates to 55-70 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human MVK Protein 5009
$300.00 – $1,000.00
Summary
- Expression: Baculovirus-Insect Cells
- Pure: Yes (SDS-PAGE)
- Amino Acid Range: Met1-Leu396
Human MVK Protein 5009
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Mevalonate kinase (MK) is an essential enzyme in the mevalonate pathway which produces numerous cellular isoprenoids. The enzyme has been characterized both at the biochemical and the molecular level in a variety of organisms. Despite the fact that mevalonate kinase is not the rate-limiting enzyme in isoprenoid biosynthesis, its activity is subject to feedback regulation by the branch-point intermediates geranyldiphosphate, farnesyldiphosphate and geranylgeranyldiphosphate. |
Protein names Mevalonate kinase (MK) (EC 2.7.1.36) |
Gene names MVK,MVK |
Protein family GHMP kinase family, Mevalonate kinase subfamily |
Mass 9606Da |
Function Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419). |
Catalytic activity BINDING 13; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 55; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 135; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 140..146; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 146; /ligand="Mg(2+)"; /ligand_id="ChEBI:CHEBI:18420"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 193; /ligand="Mg(2+)"; /ligand_id="ChEBI:CHEBI:18420"; /evidence="ECO:0000250|UniProtKB:P17256" |
Pathway PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. |
Subellular location Cytoplasm. Peroxisome . |
Structure Homodimer. |
Target Relevance information above includes information from UniProt accession: Q03426 |
The UniProt Consortium |
Publications
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