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Human MVK Protein 5009

$300.00$1,000.00

Summary

  • Expression: Baculovirus-Insect Cells
  • Pure: Yes (SDS-PAGE)
  • Amino Acid Range: Met1-Leu396
SKU: 5009parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q03426

express system

Baculovirus-Insect Cells

product tag

N-His-GST, C-Strep-II

purity

> 90% as determined by Tris-Bis PAGE

background

Mevalonate kinase (MK) is an essential enzyme in the mevalonate pathway which produces numerous cellular isoprenoids. The enzyme has been characterized both at the biochemical and the molecular level in a variety of organisms. Despite the fact that mevalonate kinase is not the rate-limiting enzyme in isoprenoid biosynthesis, its activity is subject to feedback regulation by the branch-point intermediates geranyldiphosphate, farnesyldiphosphate and geranylgeranyldiphosphate.

molecular weight

The protein has a predicted MW of 72.23 kDa. The protein migrates to 55-70 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human MVK Protein 5009

protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Mevalonate kinase (MK) is an essential enzyme in the mevalonate pathway which produces numerous cellular isoprenoids. The enzyme has been characterized both at the biochemical and the molecular level in a variety of organisms. Despite the fact that mevalonate kinase is not the rate-limiting enzyme in isoprenoid biosynthesis, its activity is subject to feedback regulation by the branch-point intermediates geranyldiphosphate, farnesyldiphosphate and geranylgeranyldiphosphate.
Protein names
Mevalonate kinase (MK) (EC 2.7.1.36)
Gene names
MVK,MVK
Protein family
GHMP kinase family, Mevalonate kinase subfamily
Mass
9606Da
Function
Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:11278915, PubMed:18302342, PubMed:9325256, PubMed:9392419).
Catalytic activity
BINDING 13; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 55; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 135; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 140..146; /ligand="ATP"; /ligand_id="ChEBI:CHEBI:30616"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 146; /ligand="Mg(2+)"; /ligand_id="ChEBI:CHEBI:18420"; /evidence="ECO:0000250|UniProtKB:P17256"; BINDING 193; /ligand="Mg(2+)"; /ligand_id="ChEBI:CHEBI:18420"; /evidence="ECO:0000250|UniProtKB:P17256"
Pathway
PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
Subellular location
Cytoplasm. Peroxisome .
Structure
Homodimer.
Target Relevance information above includes information from UniProt accession: Q03426
The UniProt Consortium

SDS-PAGE gel of Human MVK Protein
Human MVK on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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