Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P29376 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase that belongs to the insulin receptor family. LTK is mainly expressed in pre B cells and brain. |
molecular weight | The protein has a predicted MW of 42.31 kDa. Due to glycosylation, the protein migrates to 58-70 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human LTK protein 2766
$300.00 – $1,000.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Ile17-Pro424
Human LTK protein 2766
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Leukocyte tyrosine kinase (LTK) is a receptor tyrosine kinase that belongs to the insulin receptor family. LTK is mainly expressed in pre B cells and brain. |
Protein names Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1) |
Gene names LTK,LTK TYK1 |
Protein family Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily |
Mass 9606Da |
Function Receptor with a tyrosine-protein kinase activity (PubMed:10445845, PubMed:20548102, PubMed:30061385). Following activation by ALKAL1 or ALKAL2 ligands at the cell surface, transduces an extracellular signal into an intracellular response (PubMed:30061385, PubMed:34646012). Ligand-binding to the extracellular domain induces tyrosine kinase activation, leading to activation of the mitogen-activated protein kinase (MAPK) pathway (PubMed:20548102). Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif (By similarity). The exact function of this protein is not known; studies with chimeric proteins demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival (PubMed:18849880, PubMed:9223670). Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport (PubMed:20548102). |
Subellular location Cell membrane ; Single-pass type I membrane protein . |
Tissues Expressed in non-hematopoietic cell lines and T- and B-cell lines. |
Structure Homodimer; homodimerizes following ligand-binding (PubMed:34646012). Part of a complex including LTK, TNK2 and GRB2, in which GRB2 promotes LTK recruitment by TNK2 (PubMed:19815557). |
Post-translational modification Phosphorylated at tyrosine residues by autocatalysis, which activates kinase activity. |
Target Relevance information above includes information from UniProt accession: P29376 |
The UniProt Consortium |
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The purity of Human LTK is greater than 95% as determined by SEC-HPLC. |
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Human LTK on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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We haven't added any publications to our database yet. |
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