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Human LILRB5/CD85c/LIR-8 Protein 4604

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Arg18-His456
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

O75023

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE

background

LILRB5, also known as CD85c andLIR-8, belongs to a family of transmembrane glycoproteins that negatively regulate immune cell activation. Mature human LIR-8 consists of a 435 amino acid (aa) extracellular domain with four Ig-like domains, a 21 aa transmembrane segment, and a 111 aa cytoplasmic domain with two immunoreceptor tyrosine-based inhibitory motifs (ITIM). LILRB5 may act as receptor for class I MHC antigens.

molecular weight

The protein has a predicted MW of 49.9 kDa. Due to glycosylation, the protein migrates to 67-72 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human LILRB5/CD85c/LIR-8 Protein 4604

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
LILRB5, also known as CD85c andLIR-8, belongs to a family of transmembrane glycoproteins that negatively regulate immune cell activation. Mature human LIR-8 consists of a 435 amino acid (aa) extracellular domain with four Ig-like domains, a 21 aa transmembrane segment, and a 111 aa cytoplasmic domain with two immunoreceptor tyrosine-based inhibitory motifs (ITIM). LILRB5 may act as receptor for class I MHC antigens.
Protein names
Leukocyte immunoglobulin-like receptor subfamily B member 5 (CD85 antigen-like family member C) (Leukocyte immunoglobulin-like receptor 8) (LIR-8) (CD antigen CD85c)
Gene names
LILRB5,LILRB5 LIR8
Mass
9606Da
Function
FUNCTION: May act as receptor for class I MHC antigens.
Subellular location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Tissues
TISSUE SPECIFICITY: Detected in a natural killer (NK) cells. {ECO:0000269|PubMed:9548455}.
Domain
DOMAIN: Co
Target Relevance information above includes information from UniProt accession : O75023
The UniProt Consortium

Data

HPLC of Human LILRB5/CD85c/LIR-8 Protein
The purity of Human LILRB5 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human LILRB5/CD85c/LIR-8 Protein
Human LILRB5 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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