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Human LAMP5 Protein 5067

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Glu30-Glu235
SKU: 5067parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q9UJQ1

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord.

molecular weight

The protein has a predicted MW of 24.17 kDa. Due to glycosylation, the protein migrates to 30-40 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human LAMP5 Protein 5067

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord.
Protein names
Lysosome-associated membrane glycoprotein 5 (Brain and dendritic cell-associated LAMP) (Brain-associated LAMP-like protein) (BAD-LAMP) (Lysosome-associated membrane protein 5) (LAMP-5)
Gene names
LAMP5,LAMP5 C20orf103
Protein family
LAMP family
Mass
9606Da
Function
Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain.
Subellular location
Cell membrane ; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane ; Single-pass type I membrane protein. Endosome membrane ; Single-pass type I membrane protein. Cytoplasmic vesicle membrane ; Single-pass type I membrane protein. Cell projection, dendrite. Cell projection, growth cone membrane ; Single-pass type I membrane protein. Early endosome membrane ; Single-pass type I membrane protein. Recycling endosome. Note=Recycles from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane (By similarity). Colocalizes with UNC93B1 in large endosomal intracellular vesicles (PubMed:21642595). Accumulates in the endoplasmic reticulum-Golgi intermediate compartment (ERGIC) before its disappearance upon activation by CpG dinucleotides (PubMed:21642595). Associates with cortical membranes (PubMed:21642595). Localizes mostly in cytoplasmic vesicles of neuronal cell body (By similarity). Localizes to synaptic vesicles in a subset of GABAergic neurons (By similarity).
Tissues
Expressed in plasmocytoid dendritic cells. Expressed in suprabasal skin keratinocytes and squamous cells (at protein level). Expressed in the brain and weakly in spleen and skin. Expressed in plasmocytoid dendritic cells.
Post-translational modification
Glycosylated.
Target Relevance information above includes information from UniProt accession: Q9UJQ1
The UniProt Consortium

HPLC of Human LAMP5 Protein
The purity of Human LAMP5 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human LAMP5 Protein
Human LAMP5 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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