Human Laminin 521 Protein (PG) 2562

$75.00 – $250.00

Summary

Mammalian expression:

SKU: 2562parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	0
express system	0
product tag
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background
molecular weight	tbd
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human Laminin 521 Protein (PG) 2562

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Protein names Interleukin-33
Gene names IL33,IL33
Protein family IL-1 family
Mass 30458Da
Function FUNCTION: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation. {ECO:0000256\|ARBA:ARBA00045203}.
Subellular location SUBCELLULAR LOCATION: Chromosome {ECO:0000256\|ARBA:ARBA00004286}. Cytoplasmic vesicle, secretory vesicle {ECO:0000256\|ARBA:ARBA00004398}. Nucleus {ECO:0000256\|ARBA:ARBA00004123}. Secreted {ECO:0000256\|ARBA:ARBA00004613}.
Structure SUBUNIT: Forms a 1:1:1 heterotrimeric complex with its primary high-affinity receptor IL1RL1 and the coreceptor IL1RAP. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion. {ECO:0000256\|ARBA:ARBA00046367}.
Target Relevance information above includes information from UniProt accession: A0A2K5W3I1
The UniProt Consortium

Data

3D model

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.