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Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein 4399

$375.00$1,250.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P06756(ITGAV)&P18564(ITGB6)

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.

molecular weight

The protein has a predicted MW of 114 kDa (ITGAV)&79.1 kDa (ITGB6). Due to glycosylation, the protein migrates to 90-150 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein 4399

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
No information
target relevance

Data

ELISA with Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Prot
Immobilized Human ITGAV&ITGB6, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Human Latent TGF beta 1, His Tag with the EC50 of 63.3ng/ml determined by ELISA.
HPLC of Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein
The purity of Human ITGAV&ITGB6 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer
Human ITGAV&ITGB6 on Tris-Bis PAGE under reduced conditions. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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Protocols

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