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Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein 3333

$375.00$1,250.00

Summary

  • Expression: HEK293
  • Pure: Yes (HPLC)
  • Amino Acid Range: Leu32-Arg993(ITGA2B) acidic tail & GLy27-Asp718(ITGB3) basic tail
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P08514(ITGA2B)&P05106(ITGB3)

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Glanzmann thrombasthenia (GT) is characterized by mucocutaneous bleeding due to platelets that fail to aggregate in response to physiologic stimuli. GT, a rare inherited disease, is caused by quantitative or qualitative deficiencies of αIIbβ3, an integrin receptor for adhesive proteins. Coded by the ITGA2B and ITGB3 genes, αIIbβ3 mediates platelet-to-platelet attachment, aggregation and clot retraction.

molecular weight

The protein has a predicted MW of 110.5 kDa (ITGA2B)&81.3 kDa (ITGB3). Due to glycosylation, the protein migrates to 95-115 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Protein 3333

Data

HPLC of Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodimer Prote
The purity of Human ITGA2B&ITGB3 is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human Integrin alpha 2B beta 3 (ITGA2B&ITGB3) Heterodim
Human ITGA2B&ITGB3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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