Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P16871(IL-7 R alpha)&Q9HC73(TSLPR) |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | IL-7R alpha & TSLPR is an heterodimeric receptor, with TSLP as the ligand, which initiates downstream signaling pathways upon binding to TSLP and subsequently participates in thymus development and immune cell generation. Among them, IL-7R alpha is a component of both the IL-7 and TSLP receptors. |
molecular weight | The protein has a predicted MW of 31.18 kDa (IL-7 R alpha) and 29.03 kDa (TSLPR). Due to glycosylation, the protein migrates to 58-68 kDa (IL-7 R alpha) and 50-58 kDa (TSLPR) based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human IL-7 R alpha&TSLPR Protein 2006
$345.00 – $1,150.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Glu21-Asp239(IL-7 R alpha) & Gln23-Lys231(TSLPR)
Human IL-7 R alpha&TSLPR Protein 2006
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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IL-7R alpha & TSLPR is an heterodimeric receptor, with TSLP as the ligand, which initiates downstream signaling pathways upon binding to TSLP and subsequently participates in thymus development and immune cell generation. Among them, IL-7R alpha is a component of both the IL-7 and TSLP receptors. |
Protein names Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127) |
Protein family Type I cytokine receptor family, Type 4 subfamily |
Mass 51579Da |
Function Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
Subellular location [Isoform 1]: Cell membrane; Single-pass type I membrane protein {ECO:0000269|PubMed:31748347}.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; [Isoform 4]: Secreted. |
Structure The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. Interacts with CD53 (PubMed:31748347). {ECO:0000269|PubMed:19141282, ECO:0000269|PubMed:31748347}. |
Post-translational modification N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form. {ECO:0000269|PubMed:19141282}. |
Domain The WSXWS motif appears to be necessary for proper protein folding and thereby efficient int |
Target Relevance information above includes information from UniProt accession: P16871 |
The UniProt Consortium |
Publications
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