Human ICAM-3/CD50 Protein 3257

$270.00 – $900.00

Summary

Expression: HEK293
Pure: Yes (SDS-PAGE)
Amino Acid Range: Gln30-His485

SKU: 3257parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	CAA49369
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE
background	ICAM-3 interacts with LFA1, and is involved in the intercellular adhesion of leukocytes as well as in the mainenance of cell survival. ICAM-3 expression induces cancer cell proliferation, and an increase in ICAM-3 expression can contribute to cancer progression.
molecular weight	The protein has a predicted MW of 50.54 kDa. Due to glycosylation, the protein migrates to 80-110 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human ICAM-3/CD50 Protein 3257

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
ICAM-3 interacts with LFA1, and is involved in the intercellular adhesion of leukocytes as well as in the mainenance of cell survival. ICAM-3 expression induces cancer cell proliferation, and an increase in ICAM-3 expression can contribute to cancer progression.
Protein names Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)
Protein family Immunoglobulin superfamily, ICAM family
Mass 59541Da
Function ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2) (PubMed:1448173). ICAM3 is also a ligand for integrin alpha-D/beta-2. In association with integrin alpha-L/beta-2, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). {ECO:0000269\|PubMed:1448173, ECO:0000269\|PubMed:23775590}.
Subellular location Membrane; Single-pass type I membrane protein.
Tissues Leukocytes. {ECO:0000269\|PubMed:1448173, ECO:0000269\|PubMed:23775590}.
Structure Interacts with moesin/MSN. {ECO:0000269\|PubMed:9298994}.
Post-translational modification Upon stimulation by a physiologic stimuli becomes rapidly and transiently phosphorylated on serine residues.; N-glycosylated; glycans consist of a mixture of tri- and tetra-antennary complex-type chains and high-mannose chains. {ECO:0000269\|PubMed:15728350, ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19159218, ECO:0000269\|PubMed:19349973}.
Target Relevance information above includes information from UniProt accession: P32942
The UniProt Consortium

Data

SDS-PAGE gel of Human ICAM-3/CD50 Protein

Human ICAM-3 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.