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Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein 3314

$750.00$3,000.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gly25-Thr305(HLA-A*11:01),Ile21-Met119(B2M)and VVVGADGVGK peptide
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

AAV53343(HLA-A*11:01)&P61769(B2M)&VVVGADGVGK

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

molecular weight

The protein has a predicted MW of 258 kDa. Due to glycosylation, the protein migrates to 260-265 kDa under Non reducing (N) condition based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein 3314

Data

ELISA with Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protei
Immobilized HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) TCR at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer, His Tag with the EC50 of 51.5ng/ml determined by ELISA.
HPLC of Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer Protein
The purity of Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer P
Human HLA-A*11:01&B2M&KRAS G12D (VVVGADGVGK) Tetramer on Tris-Bis PAGE under Non reducing (N) condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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