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Human HLA-A*02:01&B2M&CMVpp65 (NLVPMVATV) Tetramer Protein 2050

$750.00$3,000.00

Summary

  • Expression: E.coli
  • Pure: Yes (HPLC)
  • Amino Acid Range: Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and NLVPMVATV peptide
SKU: 2050parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

A0A140T913(HLA-A*02:01)&P61769(B2M)&NLVPMVATV

express system

E.coli

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Human cytomegalovirus (CMV), a β-herpes virus with a double-stranded DNA, infects a wide variety of cells and establishes latency in the host. CMVpp65, a tegument protein of the herpes virus CMV, is the main viral antigen found in peripheral blood mononuclear cells (PBMCs) after viral infection and may activate cell-mediated immunity, accounting for 70-90% of the cytotoxic CD8+ T cells' (CTLs) response to CMV. Among the pp65-derived CTL epitope peptides, the 9-mer peptide 495NLVPMVATV503 (CMVpp65 495-503 peptide) is the most immunogenic T cell epitope predominantly displayed on HLA-A*02:01, the most common MHC-I allele in the population.

molecular weight

The protein has a predicted MW of 258 kDa. The protein migrates to 120-180 kDa (HLA-A*02:01&streptavidin tetramer) and 11.9 kDa (B2M) based on Tris-Bis PAGE result under Non reducing (N) condition.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human HLA-A*02:01&B2M&CMVpp65 (NLVPMVATV) Tetramer Protein 2050

protein
Size and concentration
100, 500µg and liquid
Form
Liquid
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped with dry ice.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Human cytomegalovirus (CMV), a β-herpes virus with a double-stranded DNA, infects a wide variety of cells and establishes latency in the host. CMVpp65, a tegument protein of the herpes virus CMV, is the main viral antigen found in peripheral blood mononuclear cells (PBMCs) after viral infection and may activate cell-mediated immunity, accounting for 70-90% of the cytotoxic CD8+ T cells' (CTLs) response to CMV. Among the pp65-derived CTL epitope peptides, the 9-mer peptide 495NLVPMVATV503 (CMVpp65 495-503 peptide) is the most immunogenic T cell epitope predominantly displayed on HLA-A*02:01, the most common MHC-I allele in the population.
Protein names
Major histocompatibility complex, class I, A
Gene names
HLA-A,HLA-A
Protein family
MHC class I family
Mass
41449Da
Target Relevance information above includes information from UniProt accession: A0A140T913
The UniProt Consortium

HPLC of Human HLA-A*02:01&B2M&CMVpp65 (NLVPMVATV) Tetramer Protein
The purity of Human HLA-A*02:01&B2M&CMVpp65 (NLVPMVATV) Tetramer is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human HLA-A*02:01&B2M&CMVpp65 (NLVPMVATV) Tetramer Prot
Human HLA-A*02:01&B2M&CMVpp65 (NLVPMVATV) Tetramer on Tris-Bis PAGE under Non reducing (N) condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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