Human GPRC5D Protein-VLP 4304

$1,100.00 – $3,800.00

Summary

Expression: HEK293
Functional: Yes (ELISA)
Amino Acid Range: Met1-Val345

SKU: 4304parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q9NZD1
express system	HEK293
product tag
purity	> 95% as determined by HPLC
background	Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA.
molecular weight	The target protein has a predicted MW of 39.6 kDa.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human GPRC5D Protein-VLP 4304

protein

Size and concentration 100, 500µg and liquid
Form Liquid
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped with dry ice.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G proteinâ€“coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA.
Protein names G-protein coupled receptor family C group 5 member D
Gene names GPRC5D,GPRC5D
Protein family G-protein coupled receptor 3 family
Mass 9606Da
Subellular location Cell membrane ; Multi-pass membrane protein .
Tissues Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscle and ovary.
Target Relevance information above includes information from UniProt accession: Q9NZD1
The UniProt Consortium

Data

Immobilized Human GPRC5D VLP at 5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-GPRC5D Antibody, hFc Tag with the EC50 of 3.8ng/ml determined by ELISA.

The purity of Human GPRC5D VLP is greater than 95% as determined by SEC-HPLC.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.