Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P55075 |
express system | E.coli |
product tag | No Tag |
purity | > 95% as determined by Tris-Bis PAGE |
background | Two of the four human FGF8 splice isoforms, FGF8a and FGF8b, are expressed in the mid-hindbrain region during development. Although the only difference between these isoforms is the presence of an additional 11 amino acids at the N terminus of FGF8b, these isoforms possess remarkably different abilities to pattern the midbrain and anterior hindbrain. |
molecular weight | The protein has a predicted MW of 21.20 kDa same as Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 0.01 EU per μg by the LAL method. |
Human FGF8a Protein 2478
$300.00 – $1,000.00
Summary
- Expression: E.coli
- Active: Yes (cell based assay)
- Amino Acid Range: Gln23-Arg204
Human FGF8a Protein 2478
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Two of the four human FGF8 splice isoforms, FGF8a and FGF8b, are expressed in the mid-hindbrain region during development. Although the only difference between these isoforms is the presence of an additional 11 amino acids at the N terminus of FGF8b, these isoforms possess remarkably different abilities to pattern the midbrain and anterior hindbrain. |
Protein names Fibroblast growth factor 8 (FGF-8) (Androgen-induced growth factor) (AIGF) (Heparin-binding growth factor 8) (HBGF-8) |
Gene names FGF8,FGF8 AIGF |
Protein family Heparin-binding growth factors family |
Mass 9606Da |
Function Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system (PubMed:16384934, PubMed:16597617, PubMed:8663044). Plays a role in neurite outgrowth in hippocampal cells (PubMed:21576111). |
Subellular location Secreted. |
Structure Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. |
Target Relevance information above includes information from UniProt accession: P55075 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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