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Human DLL3 Domain (311-479) Protein 2612

$1,000.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Val311-Ala479
SKU: 2612parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

Q9NYJ7

express system

HEK293

product tag

C-His-Avi

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).

molecular weight

The protein has a predicted MW of 21.20 kDa. Due to glycosylation, the protein migrates to 25-30 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human DLL3 Domain (311-479) Protein 2612

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Protein names
Delta-like protein 3 (Drosophila Delta homolog 3) (Delta3)
Gene names
DLL3,DLL3
Mass
9606Da
Function
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).
Subellular location
Membrane ; Single-pass type I membrane protein .
Structure
Can bind and activate Notch-1 or another Notch receptor.
Post-translational modification
Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
Domain
Th
Target Relevance information above includes information from UniProt accession: Q9NYJ7
The UniProt Consortium

ELISA with Human DLL3 Domain (311-479) Protein
Immobilized Human DLL3 Domain (311-479), His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Anti-DLL3 Antibody, hFc Tag with the EC50 of 2.9ng/ml determined by ELISA.
HPLC of Human DLL3 Domain (311-479) Protein
The purity of Human DLL3 Domain (311-479) is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human DLL3 Domain (311-479) Protein
Human DLL3 Domain (311-479) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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