Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P09871 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE |
background | Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrome, and acute respiratory distress syndrome (ARDS). |
molecular weight | The protein has a predicted MW of 75.98 kDa. Due to enzyme lysis glycosylation, the protein migrates to 55-60 kDa (light chain), 32-35 kDa (heavy chain) and 76-96 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human Complement Component C1s Protein 2703
$315.00 – $1,050.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Glu16-Asp688
Human Complement Component C1s Protein 2703
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrome, and acute respiratory distress syndrome (ARDS). |
Protein names Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain] |
Gene names C1S,C1S |
Protein family Peptidase S1 family |
Mass 9606Da |
Function C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. |
Catalytic activity BINDING 60; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 68; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 113; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 131; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 132; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 134; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 149; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 150; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 153; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108" |
Structure C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain. |
Post-translational modification The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. |
Target Relevance information above includes information from UniProt accession: P09871 |
The UniProt Consortium |
Publications
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