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Human Complement Component C1s Protein 2703

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Glu16-Asp688
SKU: 2703parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P09871

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE

background

Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrome, and acute respiratory distress syndrome (ARDS).

molecular weight

The protein has a predicted MW of 75.98 kDa. Due to enzyme lysis glycosylation, the protein migrates to 55-60 kDa (light chain), 32-35 kDa (heavy chain) and 76-96 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human Complement Component C1s Protein 2703

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrome, and acute respiratory distress syndrome (ARDS).
Protein names
Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]
Gene names
C1S,C1S
Protein family
Peptidase S1 family
Mass
9606Da
Function
C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4.
Catalytic activity
BINDING 60; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 68; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 113; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 131; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 132; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 134; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 149; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 150; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"; BINDING 153; /ligand="Ca(2+)"; /ligand_id="ChEBI:CHEBI:29108"
Structure
C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. Activated C1s is an disulfide-linked heterodimer of a heavy chain and a light chain.
Post-translational modification
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
Target Relevance information above includes information from UniProt accession: P09871
The UniProt Consortium

ELISA with Human Complement Component C1s Protein
Immobilized Human Complement Component C1S, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-C1S Antibody, hFc Tag with the EC50 of 9.6ng/ml determined by ELISA.
SDS-PAGE gel of Human Complement Component C1s Protein
Human Complement Component C1s on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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