Human CLEC4M/CD299 Protein 2266

$315.00 – $1,050.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Gln71-Glu399

SKU: 2266parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	Q9H2X3
express system	HEK293
product tag	N-His-Flag
purity	> 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC
background	CLEC4M, also known as DC-SIGNR, L-SIGN or CD209L, is a Ca2+-dependent C-type lectin. CLEC4M and its homologue DC-SIGN are encoded by the closely related lectin gene cluster on chromosome 19p13.3. higher expression of CLEC4M is associated with poor clinical prognosis in lung cancer patients and enhances the resistance of NSCLC cells to cisplatin. Inhibition of CLEC4M expression significantly increased cisplatin sensitivity, suggesting potential clinical significance for targeting CLEC4M in overcoming cisplatin resistance.
molecular weight	The protein has a predicted MW of 39.81 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human CLEC4M/CD299 Protein 2266

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CLEC4M, also known as DC-SIGNR, L-SIGN or CD209L, is a Ca2+-dependent C-type lectin. CLEC4M and its homologue DC-SIGN are encoded by the closely related lectin gene cluster on chromosome 19p13.3. higher expression of CLEC4M is associated with poor clinical prognosis in lung cancer patients and enhances the resistance of NSCLC cells to cisplatin. Inhibition of CLEC4M expression significantly increased cisplatin sensitivity, suggesting potential clinical significance for targeting CLEC4M in overcoming cisplatin resistance.
Protein names C-type lectin domain family 4 member M (CD209 antigen-like protein 1) (DC-SIGN-related protein) (DC-SIGNR) (Dendritic cell-specific ICAM-3-grabbing non-integrin 2) (DC-SIGN2) (Liver/lymph node-specific ICAM-3-grabbing non-integrin) (L-SIGN) (CD antigen CD299)
Gene names CLEC4M,CLEC4M CD209L CD209L1 CD299
Mass 9606Da
Function Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates.; (Microbial infection) Acts as an attachment receptor for Ebolavirus.; (Microbial infection) Acts as an attachment receptor for Hepatitis C virus.; (Microbial infection) Acts as an attachment receptor for HIV-1.; (Microbial infection) Acts as an attachment receptor for Human coronavirus 229E.; (Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5.; (Microbial infection) Acts as an attachment receptor for Influenzavirus.; (Microbial infection) Acts as an attachment receptor for SARS-CoV.; (Microbial infection) Acts as an attachment receptor for West-nile virus.; (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.; (Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein.; (Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule.
Subellular location [Isoform 1]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 2]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 3]: Cell membrane ; Single-pass type II membrane protein .; [Isoform 5]: Secreted .; [Isoform 6]: Secreted .; [Isoform 7]: Secreted .; [Isoform 10]: Secreted .
Tissues Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells.
Structure Homotetramer.; (Microbial infection) Interacts with ebola virus glycoprotein (PubMed:12050398, PubMed:12502850).; (Microbial infection) Interacts with hepatitis C virus E1 and E2 protein (PubMed:15371595, PubMed:16816373).; (Microbial infection) Interacts with HIV-1 gp120 (PubMed:12502850, PubMed:21277928).; (Microbial infection) Interacts with human coronavirus 229E spike glycoprotein.; (Microbial infection) Interacts with human cytomegalovirus/HHV-5 gB protein.; (Microbial infection) Interacts with influenzavirus hemagglutinin.; (Microbial infection) Interacts with SARS-CoV spike glycoprotein.; (Microbial infection) Interacts with west-nile virus envelope protein E.; (Microbial infection) Interacts with Japanese encephalitis virus E protein.; (Microbial infection) Interacts with Marburg virus glycoprotein.; (Microbial infection) Interacts with M.bovis LprG.
Domain Th
Target Relevance information above includes information from UniProt accession: Q9H2X3
The UniProt Consortium

The purity of Human CLEC4M is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human CLEC4M/CD299 Protein

Human CLEC4M on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.