Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q5QGZ9 |
express system | HEK293 |
product tag | N-hFc |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. |
molecular weight | The protein has a predicted MW of 50.9 kDa. Due to glycosylation, the protein migrates to 68-73 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human CLEC12A/MICL/CLL-1 Protein 4402
$345.00 – $1,150.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: His65-Ala265
Human CLEC12A/MICL/CLL-1 Protein 4402
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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CLEC12A has recently been identified as an antigen, expressed on leukemic stem cells and leukemic blasts. Given the fact that this expression profile seems stable throughout diagnosis, treatment and relapse on leukemic blasts and leukemic stem cells, CLEC12A can be considered a highly potent and reliable marker for the detection of measurable residual disease and therefore applicable for risk stratification and prognostication in AML. |
Protein names C-type lectin domain family 12 member A (C-type lectin-like molecule 1) (CLL-1) (Dendritic cell-associated lectin 2) (DCAL-2) (Myeloid inhibitory C-type lectin-like receptor) (MICL) (CD antigen CD371) |
Gene names CLEC12A,CLEC12A CLL1 DCAL2 MICL |
Mass 9606Da |
Function Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. |
Subellular location Cell membrane ; Single-pass type II membrane protein. Note=Ligand binding leads to internalization. |
Tissues Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages. |
Structure Interacts with PTPN6 and PTPN11. |
Post-translational modification Highly N-glycosylated. Glycosylation varies between cell types. |
Domain Co |
Target Relevance information above includes information from UniProt accession: Q5QGZ9 |
The UniProt Consortium |
Data
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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Documents
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