Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P06731 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
background | Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated. |
molecular weight | The protein has a predicted MW of 20.66 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1 EU per μg by the LAL method. |
Human CEACAM-5/CD66e (145-322) Protein 2229
$345.00 – $1,150.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Pro145-Pro322
Human CEACAM-5/CD66e (145-322) Protein 2229
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated. |
Protein names Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) |
Gene names CEACAM5,CEACAM5 CEA |
Protein family Immunoglobulin superfamily, CEA family |
Mass 9606Da |
Function Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:10864933, PubMed:10910050, PubMed:2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050).; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. |
Subellular location Cell membrane ; Lipid-anchor, GPI-anchor. Apical cell membrane. Cell surface. Note=Localized to the apical glycocalyx surface. |
Tissues Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. |
Structure Homodimer. |
Post-translational modification Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate. |
Target Relevance information above includes information from UniProt accession: P06731 |
The UniProt Consortium |
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The purity of Human CEACAM-5 (145-322) is greater than 95% as determined by SEC-HPLC. |
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Human CEACAM-5 (145-322) on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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