Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q12864 |
express system | HEK293 |
product tag | C-mFc |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
molecular weight | The protein has a predicted MW of 50.18 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human CDH17/Cadherin 17 Domain 6-7 Protein 2651
$390.00 – $1,300.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Ser567-Gly777
Human CDH17/Cadherin 17 Domain 6-7 Protein 2651
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Protein names Cadherin-17 (Intestinal peptide-associated transporter HPT-1) (Liver-intestine cadherin) (LI-cadherin) |
Gene names CDH17,CDH17 |
Mass 9606Da |
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport. |
Subellular location Cell membrane ; Single-pass type I membrane protein . |
Tissues Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin. |
Domain Th |
Target Relevance information above includes information from UniProt accession: Q12864 |
The UniProt Consortium |
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The purity of Human CDH17 Domain 6-7 is greater than 95% as determined by SEC-HPLC. |
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Human CDH17 Domain 6-7 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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We haven't added any publications to our database yet. |
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