Human CDH11/Cadherin 11 Protein 3344

$315.00 – $1,050.00

Summary

Expression: HEK293
Pure: Yes (SDS-PAGE)
Amino Acid Range: Gly54-Thr617

SKU: 3344parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	AAA35622
express system	HEK293
product tag	C-His
purity	> 90% as determined by Tris-Bis PAGE
background	CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. CDH11 mediates homophilic cell-to-cell adhesion, which may promote the development of cirrhosis. CDH11 expression was positively correlated with liver fibrosis in patients with cirrhosis, and could therefore be a prognostic factor in patients with liver fibrosis.
molecular weight	The protein has a predicted MW of 66.32 kDa. Due to glycosylation, the protein migrates to 67-70 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human CDH11/Cadherin 11 Protein 3344

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CDH11 belongs to a group of transmembrane proteins that are principally located in adherens junctions. CDH11 mediates homophilic cell-to-cell adhesion, which may promote the development of cirrhosis. CDH11 expression was positively correlated with liver fibrosis in patients with cirrhosis, and could therefore be a prognostic factor in patients with liver fibrosis.
Protein names Cadherin-11 (OSF-4) (Osteoblast cadherin) (OB-cadherin)
Mass 87965Da
Function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546). {ECO:0000269\|PubMed:33811546}.
Subellular location Cell membrane; Single-pass type I membrane protein.
Tissues Expressed mainly in brain but also found in other tissues. Expressed in neuroblasts. In the embryo from 67 to 72 days of gestation, detected at high levels in facial mesenchyme including the central palatal mesenchyme, dental mesenchyme, the eye and optic muscle, and the tongue (at protein level) (PubMed:33811546). {ECO:0000269\|PubMed:33811546}.
Structure Interacts with PCDH8. {ECO:0000250}.
Domain Three calcium ions are usually bound at the interface of each cadherin domain and rigidify t
Target Relevance information above includes information from UniProt accession: P55287
The UniProt Consortium

Data

SDS-PAGE gel of Human CDH11/Cadherin 11 Protein

Human CDH11 on Tris-Bis PAGE under reduced condition. The purity is greater than 90%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.