Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P21854 |
express system | HEK293 |
product tag | N-His |
purity | > 95% as determined by Tris-Bis PAGE |
background | CD72 (originally Lyb-2), a 45 kDa type II transmembrane glycoprotein. CD72 belongs to the calcium-dependent C-type lectin superfamily and shares sequence homology with CD23 (the B-cell-specific low-affinity Fc receptor for IgE) and the asialoglycoprotein receptors. It is expressed as a disulfide-linked homodimer from the pro-B through the mature B-cell stage, but it is downregulated on terminally differentiated plasma cells. |
molecular weight | The protein has a predicted MW of 29.17 kDa. Due to glycosylation, the protein migrates to 32-40 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human CD72 Protein 2543
$270.00 – $900.00
Summary
- Expression: HEK293
- Pure: Yes (SDS-PAGE)
- Amino Acid Range: Arg117-Asp359
Human CD72 Protein 2543
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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CD72 (originally Lyb-2), a 45 kDa type II transmembrane glycoprotein. CD72 belongs to the calcium-dependent C-type lectin superfamily and shares sequence homology with CD23 (the B-cell-specific low-affinity Fc receptor for IgE) and the asialoglycoprotein receptors. It is expressed as a disulfide-linked homodimer from the pro-B through the mature B-cell stage, but it is downregulated on terminally differentiated plasma cells. |
Protein names B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72) |
Gene names CD72,CD72 |
Mass 9606Da |
Function Plays a role in B-cell proliferation and differentiation. |
Subellular location Membrane; Single-pass type II membrane protein. |
Tissues Pre-B-cells and B-cells but not terminally differentiated plasma cells. |
Structure Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity). |
Post-translational modification Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity). |
Target Relevance information above includes information from UniProt accession: P21854 |
The UniProt Consortium |
Publications
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