Skip to content

Human CD72 Protein 2543

$270.00$900.00

Summary

  • Expression: HEK293
  • Pure: Yes (SDS-PAGE)
  • Amino Acid Range: Arg117-Asp359
SKU: 2543parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P21854

express system

HEK293

product tag

N-His

purity

> 95% as determined by Tris-Bis PAGE

background

CD72 (originally Lyb-2), a 45 kDa type II transmembrane glycoprotein. CD72 belongs to the calcium-dependent C-type lectin superfamily and shares sequence homology with CD23 (the B-cell-specific low-affinity Fc receptor for IgE) and the asialoglycoprotein receptors. It is expressed as a disulfide-linked homodimer from the pro-B through the mature B-cell stage, but it is downregulated on terminally differentiated plasma cells.

molecular weight

The protein has a predicted MW of 29.17 kDa. Due to glycosylation, the protein migrates to 32-40 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human CD72 Protein 2543

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
CD72 (originally Lyb-2), a 45 kDa type II transmembrane glycoprotein. CD72 belongs to the calcium-dependent C-type lectin superfamily and shares sequence homology with CD23 (the B-cell-specific low-affinity Fc receptor for IgE) and the asialoglycoprotein receptors. It is expressed as a disulfide-linked homodimer from the pro-B through the mature B-cell stage, but it is downregulated on terminally differentiated plasma cells.
Protein names
B-cell differentiation antigen CD72 (Lyb-2) (CD antigen CD72)
Gene names
CD72,CD72
Mass
9606Da
Function
Plays a role in B-cell proliferation and differentiation.
Subellular location
Membrane; Single-pass type II membrane protein.
Tissues
Pre-B-cells and B-cells but not terminally differentiated plasma cells.
Structure
Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).
Post-translational modification
Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1 (By similarity).
Target Relevance information above includes information from UniProt accession: P21854
The UniProt Consortium

SDS-PAGE gel of Human CD72 Protein
Human CD72 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmidtitleauthorscitation
We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

relevant to this product
#
Please enter your product and batch number here to retrieve product datasheet, SDS, and QC information.

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.