| Weight | 1 lbs |
|---|---|
| Dimensions | 9 × 5 × 2 in |
| accession | P49961 |
| express system | HEK293 |
| product tag | C-His |
| purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| background | CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues.CD39 is involved in the processes of thromboregulation and vascular inflammation. The administration of soluble NTPDase-1 may have therapeutic applications for the treatment of some vascular and transplantation-associated diseases . |
| molecular weight | The protein has a predicted MW of 51.91 kDa. Due to glycosylation, the protein migrates to 65-75 kDa based on Tris-Bis PAGE result. |
| available size | 100 µg, 500 µg |
| endotoxin | Less than 1EU per μg by the LAL method. |
Human CD39/ENTPD1 Protein 2085
$375.00 – $1,250.00
Summary
- Expression: HEK293
- Active: Yes (catalytic)
- Amino Acid Range: Thr38-Val478
Human CD39/ENTPD1 Protein 2085
| protein |
|---|
| Size and concentration 100, 500µg and liquid |
| Form Liquid |
| Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Storage buffer Shipped with dry ice. |
| Purity > 95% as determined by Tris-Bis PAGE |
| target relevance |
|---|
| CD39, also known as ENTPD1, belongs to the GDA1/CD39 NTPase family. It is expressed primarily on activated lymphoid cells and can also be detected in endothelial tissues.CD39 is involved in the processes of thromboregulation and vascular inflammation. The administration of soluble NTPDase-1 may have therapeutic applications for the treatment of some vascular and transplantation-associated diseases . |
| Protein names Ectonucleoside triphosphate diphosphohydrolase 1 (EC 3.6.1.5) (ATP diphosphohydrolase) (ATP-DPH) (ATPDase) (Ecto-ATP diphosphohydrolase 1) (Ecto-ATPDase 1) (Ecto-ATPase 1) (Ecto-apyrase) (Lymphoid cell activation antigen) (Nucleoside triphosphate diphosphohydrolase 1) (NTPDase1) (CD antigen CD39) |
| Gene names ENTPD1,ENTPD1 CD39 |
| Protein family GDA1/CD39 NTPase family |
| Mass 9606Da |
| Function Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (PubMed:8955160, PubMed:8996251). |
| Subellular location Membrane ; Multi-pass membrane protein. Membrane, caveola . |
| Tissues Expressed primarily on activated lymphoid cells (PubMed:7930580). Also expressed in endothelial tissues (PubMed:8955160). Highly expressed in placenta, lung, skeletal muscle, kidney (PubMed:8955160). |
| Structure Homodimer; disulfide-linked. |
| Post-translational modification N-glycosylated.; The N-terminus is blocked.; Palmitoylated on Cys-13; which is required for caveola targeting. |
| Target Relevance information above includes information from UniProt accession: P49961 |
| The UniProt Consortium |
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