Human CD300LG/Nepmucin Protein 2089

$203.00 – $675.00

Summary

Expression: HEK293
Pure: Yes (HPLC)
Amino Acid Range: Leu19-Arg247

SKU: 2089parent Categories: proteins, Recombinant proteins Tag: active proteins

Weight	1 lbs
Dimensions	9 × 5 × 2 in
accession	AAH25395
express system	HEK293
product tag	C-His
purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
background	CD300LG is a novel O-glycosylated member of the CD300 antigen-like family. Besides a classical mucin-like domain, it contains a V-type Ig domain. CD300LG binds lymphocyte L-selectin via its Ig domain and supports lymphocyte rolling via its mucin-like domain. The unique structure and function of CD300LG suggest it may play an important role in inflammation.
molecular weight	The protein has a predicted MW of 26.35 kDa. Due to glycosylation, the protein migrates to 60-80 kDa based on Tris-Bis PAGE result.
available size	100 µg, 500 µg
endotoxin	Less than 1EU per μg by the LAL method.

Human CD300LG/Nepmucin Protein 2089

protein

Size and concentration 100, 500µg and lyophilized
Form Lyophilized
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer Shipped at ambient temperature.
Purity > 95% as determined by Tris-Bis PAGE

target relevance
CD300LG is a novel O-glycosylated member of the CD300 antigen-like family. Besides a classical mucin-like domain, it contains a V-type Ig domain. CD300LG binds lymphocyte L-selectin via its Ig domain and supports lymphocyte rolling via its mucin-like domain. The unique structure and function of CD300LG suggest it may play an important role in inflammation.
Protein names CMRF35-like molecule 9 (CLM-9) (CD300 antigen-like family member G) (Triggering receptor expressed on myeloid cells 4) (TREM-4) (CD antigen CD300g)
Protein family CD300 family
Mass 36060Da
Function Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte (By similarity). {ECO:0000250}.
Subellular location Apical cell membrane {ECO:0000250\|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q1ERP8}. Basolateral cell membrane {ECO:0000250\|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q1ERP8}. Endosome, multivesicular body membrane {ECO:0000250\|UniProtKB:Q1ERP8}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:Q1ERP8}. Note=Transcytoses across the cytoplasm. {ECO:0000250\|UniProtKB:Q1ERP8}.
Tissues Highly expressed in heart, skeletal muscle and placenta. {ECO:0000269\|PubMed:16876123}.
Post-translational modification O-glycosylated with sialylated oligosaccharides. {ECO:0000250}.
Domain Ig-like V-type domain mediates binding to lymphocyte. {ECO:0000250}.
Target Relevance information above includes information from UniProt accession: Q6UXG3
The UniProt Consortium

The purity of Human CD300LG is greater than 95% as determined by SEC-HPLC.

SDS-PAGE gel of Human CD300LG/Nepmucin Protein

Human CD300LG on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

pmid	title	authors	citation
We haven't added any publications to our database yet.

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.