Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P25063 |
express system | HEK293 |
product tag | |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. |
molecular weight | The target protein has a predicted MW of 5.0 kDa. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human CD24 Protein-VLP 4350
$1,500.00 – $5,000.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Ser27-Gly59
Human CD24 Protein-VLP 4350
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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CD24 is a sialoglycoprotein expressed at the surface of most B lymphocytes and differentiating neuroblasts. It is also expressed on neutrophils and neutrophil precursors from the myelocyte stage onwards. The potential for targeting CD24 in cancer therapy seems promising, as CD24 is overexpressed in many human cancers. |
Protein names Signal transducer CD24 (Small cell lung carcinoma cluster 4 antigen) (CD antigen CD24) |
Gene names CD24,CD24 CD24A |
Protein family CD24 family |
Mass 9606Da |
Function May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). |
Subellular location Cell membrane; Lipid-anchor, GPI-anchor. |
Tissues B-cells. Expressed in a number of B-cell lines including P32/ISH and Namalwa. Expressed in erythroleukemia cell and small cell lung carcinoma cell lines. Also expressed on the surface of T-cells. |
Structure Interacts with LYN and FGR in a cell-type specific manner. Binds FRG in a small cell cancer line, LYN in the erythroleukemia cell line K-562 and in Burkitt's lymphoma. |
Post-translational modification Extensively O-glycosylated. |
Target Relevance information above includes information from UniProt accession: P25063 |
The UniProt Consortium |
Data
Immobilized Human CD24 VLP at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-CD24 Antibody, hFc Tag with the EC50 of 16.4ng/ml determined by ELISA. |
Publications
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.pmid | title | authors | citation |
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Protocols
relevant to this product |
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Documents
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