Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | Q6QNY1 |
express system | E.coli |
product tag | No Tag |
purity | > 95% as determined by Tris-Bis PAGE;> 90% as determined by HPLC |
background | BLOC1S2 (Biogenesis of lysosome-related organelles complex-1 subunit 2) protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. On the subcellular level, BLOC1S2 is expressed in an organellar-like pattern and co-localizes with mitochondria. |
molecular weight | The protein has a predicted MW of 11.35 kDa same as Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human BLOC1S2 Protein 2454
$345.00 – $1,150.00
Summary
- Expression: E.coli
- Pure: Yes (HPLC)
- Amino Acid Range: Phe2-Arg99
Human BLOC1S2 Protein 2454
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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BLOC1S2 (Biogenesis of lysosome-related organelles complex-1 subunit 2) protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. On the subcellular level, BLOC1S2 is expressed in an organellar-like pattern and co-localizes with mitochondria. |
Protein names Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC-1 subunit 2) (Centrosome-associated protein) |
Gene names BLOC1S2,BLOC1S2 BLOS2 CEAP |
Protein family BLOC1S2 family |
Mass 9606Da |
Function Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:15102850, PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (By similarity). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May play a role in cell proliferation (PubMed:15381421). |
Subellular location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Lysosome membrane. Note=Localizes to the centrosomes in a microtubule-dependent manner. |
Tissues Isoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level). |
Structure Component of the biogenesis of lysosome-related organelles complex 1 (BLOC-1) composed of BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Octamer composed of one copy each BLOC1S1, BLOC1S2, BLOC1S3, BLOC1S4, BLOC1S5, BLOC1S6, DTNBP1/BLOC1S7 and SNAPIN/BLOC1S8. Interacts directly with BLOC1S1, BLOC1S3, BLOC1S4, BLOC1S5 and SNAPIN (PubMed:15102850, PubMed:22203680). The BLOC-1 complex associates with the AP-3 protein complex and membrane protein cargos (By similarity). Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (PubMed:25898167). Interacts with gamma-tubulin (PubMed:15381421). Interacts with IFT57 (By similarity). |
Target Relevance information above includes information from UniProt accession: Q6QNY1 |
The UniProt Consortium |
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The purity of Human BLOC1S2 is greater than 90% as determined by SEC-HPLC. |
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Human BLOC1S2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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