Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P35070 |
express system | HEK293 |
product tag | C-hFc |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. |
molecular weight | The protein has a predicted MW of 36.52 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Tris-Bis PAGE result. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human Betacellulin Protein 2502
$300.00 – $1,000.00
Summary
- Expression: HEK293
- Pure: Yes (HPLC)
- Amino Acid Range: Asp32-Gln118
Human Betacellulin Protein 2502
protein |
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Size and concentration 100, 500µg and lyophilized |
Form Lyophilized |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped at ambient temperature. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Betacellulin (BTC) belongs to the epidermal growth factor (EGF) family of peptide ligands that are characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. |
Protein names Probetacellulin [Cleaved into: Betacellulin (BTC)] |
Gene names BTC,BTC |
Mass 9606Da |
Function Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. |
Subellular location [Betacellulin]: Secreted, extracellular space.; [Probetacellulin]: Cell membrane; Single-pass type I membrane protein. |
Tissues Synthesized in several tissues and tumor cells. Predominantly expressed in pancreas and small intestine. |
Structure Monomer. Interacts with EGFR and ERBB4. |
Target Relevance information above includes information from UniProt accession: P35070 |
The UniProt Consortium |
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The purity of Human Betacellulin is greater than 95% as determined by SEC-HPLC. |
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Human Betacellulin on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
Publications
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