Skip to content

Human APRIL/TNFSF13 Trimer Protein 4411

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Lys112-Leu250
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

O75888

express system

HEK293

product tag

N-His-Flag

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R.

molecular weight

The protein has a predicted MW of 49.9 kDa. Due to glycosylation, the protein migrates to 52-60 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human APRIL/TNFSF13 Trimer Protein 4411

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
The APRIL (a proliferation-inducing ligand), also known as TNFSF13, TALL2, TRDL1, and CD256, is a member of the TNF ligand superfamily.Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA, while BAFF additionally functions through BAFF R.
Protein names
Tumor necrosis factor ligand superfamily member 13 (A proliferation-inducing ligand) (APRIL) (TNF- and APOL-related leukocyte expressed ligand 2) (TALL-2) (TNF-related death ligand 1) (TRDL-1) (CD antigen CD256)
Gene names
TNFSF13,TNFSF13 APRIL TALL2 ZTNF2 UNQ383/PRO715
Protein family
Tumor necrosis factor family
Mass
27433Da
Function
FUNCTION: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. {ECO:0000269|PubMed:10973284}.
Subellular location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11571266}.
Tissues
TISSUE SPECIFICITY: Expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages.
Structure
SUBUNIT: Homotrimer. {ECO:0000305}.
Post-translational modification
PTM: The precursor is cleaved by furin. {ECO:0000269|PubMed:11571266}.
Target Relevance information above includes information from UniProt accession : O75888
The UniProt Consortium

Data

ELISA with Human APRIL/TNFSF13 Trimer Protein
Immobilized Human APRIL Trimer, His Tag at 0.1µg/ml (100µl/Well) on the plate. Dose response curve for Human BCMA, hFc Tag with the EC50 of 10.0ng/ml determined by ELISA.
HPLC of Human APRIL/TNFSF13 Trimer Protein
The purity of Human APRIL Trimer is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human APRIL/TNFSF13 Trimer Protein
Human APRIL Trimer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




pmidtitleauthorscitation

Protocols

relevant to this product

Documents

#
No results found

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.