Weight | 1 lbs |
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Dimensions | 9 × 5 × 2 in |
accession | P29274 |
express system | HEK293 |
product tag | C-His |
purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
background | Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound receptors for adenosine have been identified and cDNAs for A1, A2a, A2b, and A3 adenosine receptor subtypes have been cloned recently.Expression of A2a adenosine receptor mRNA in cranial ganglia, carotid body, and intermediate lobe of the pituitary gland similarly suggests novel sites of adenosine action during development and in the adult. |
molecular weight | The protein has a predicted MW of 45.5 kDa. |
available size | 100 µg, 500 µg |
endotoxin | Less than 1EU per μg by the LAL method. |
Human A2AR Protein-Nanodisc 2011
$1,100.00 – $3,800.00
Summary
- Expression: HEK293
- Functional: Yes (ELISA)
- Amino Acid Range: Met1-Ser412
Human A2AR Protein-Nanodisc 2011
protein |
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Size and concentration 100, 500µg and liquid |
Form Liquid |
Storage Instructions Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Storage buffer Shipped with dry ice. |
Purity > 95% as determined by Tris-Bis PAGE |
target relevance |
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Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound receptors for adenosine have been identified and cDNAs for A1, A2a, A2b, and A3 adenosine receptor subtypes have been cloned recently.Expression of A2a adenosine receptor mRNA in cranial ganglia, carotid body, and intermediate lobe of the pituitary gland similarly suggests novel sites of adenosine action during development and in the adult. |
Protein names Adenosine receptor A2a |
Gene names ADORA2A,ADORA2A ADORA2 |
Protein family G-protein coupled receptor 1 family |
Mass 9606Da |
Function Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). |
Catalytic activity BINDING 169; /ligand="adenosine"; /ligand_id="ChEBI:CHEBI:16335"; /ligand_note="agonist"; /evidence="ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO"; BINDING 253; /ligand="adenosine"; /ligand_id="ChEBI:CHEBI:16335"; /ligand_note="agonist"; /evidence="ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO"; BINDING 277; /ligand="adenosine"; /ligand_id="ChEBI:CHEBI:16335"; /ligand_note="agonist"; /evidence="ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO"; BINDING 278; /ligand="adenosine"; /ligand_id="ChEBI:CHEBI:16335"; /ligand_note="agonist"; /evidence="ECO:0000269|PubMed:21593763, ECO:0007744|PDB:2YDO" |
Subellular location Cell membrane ; Multi-pass membrane protein. Note=Colocalizes with GAS2L2 at neuronal processes. |
Structure Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (PubMed:16339847). May interact with DRD4 (PubMed:18832607). Interacts with NECAB2 (PubMed:17689978). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity). |
Post-translational modification Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface. |
Domain Th |
Target Relevance information above includes information from UniProt accession: P29274 |
The UniProt Consortium |
Publications
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We haven't added any publications to our database yet. |
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