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Human 4-1BB Ligand/TNFSF9 Trimer Protein 4546

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Arg71-Glu254
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

P41273

express system

HEK293

product tag

N-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.

molecular weight

The protein has a predicted MW of 61.8 kDa same as Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Human 4-1BB Ligand/TNFSF9 Trimer Protein 4546

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
The 4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. 4-1BB ligand (4-1BBL) is an inducible molecule present on several APC types, including B cells, macrophages and DCs.4-1BB:4-1BBL pathway seems to amplify the existing costimulatory signals, even if the engagement of 4-1BB in the presence of a strong TCR signaling can induce IL-2 production in a CD28-independent manner.
Protein names
Tumor necrosis factor ligand superfamily member 9 (4-1BB ligand) (4-1BBL)
Gene names
TNFSF9,TNFSF9
Protein family
Tumor necrosis factor family
Mass
9606Da
Function
FUNCTION: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269|PubMed:20032458}.
Subellular location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
Tissues
TISSUE SPECIFICITY: Expressed in brain, placenta, lung, skeletal muscle and kidney.
Structure
SUBUNIT: Homotrimer. {ECO:0000269|PubMed:20032458}.
Target Relevance information above includes information from UniProt accession : P41273
The UniProt Consortium

Data

ELISA with Human 4-1BB Ligand/TNFSF9 Trimer Protein
Immobilized Human 4-1BB Ligand Trimer, His Tag at 1µg/ml (100µl/Well) on the plate. Dose response curve for Human 4-1BB, hFc Tag with the EC50 of 13.7ng/ml determined by ELISA.
HPLC of Human 4-1BB Ligand/TNFSF9 Trimer Protein
The purity of Human 41BB Ligand Trimer is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Human 4-1BB Ligand/TNFSF9 Trimer Protein
Human 41BB Ligand Trimer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.




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