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Cynomolgus TSLPR Protein 2822

$315.00$1,050.00

Summary

  • Expression: HEK293
  • Functional: Yes (ELISA)
  • Amino Acid Range: Gln23-Lys231
SKU: 2822parent Categories: , Tag:
Weight1 lbs
Dimensions9 × 5 × 2 in
accession

XP_045239630

express system

HEK293

product tag

C-His

purity

> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC

background

Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex composed of the IL-7 receptor alpha chain (IL-7Ralpha) and the TSLP receptor (TSLPR, also known as CRLF2).

molecular weight

The protein has a predicted MW of 25.42 kDa. Due to glycosylation, the protein migrates to 42-52 kDa based on Tris-Bis PAGE result.

available size

100 µg, 500 µg

endotoxin

Less than 1EU per μg by the LAL method.

Cynomolgus TSLPR Protein 2822

protein
Size and concentration
100, 500µg and lyophilized
Form
Lyophilized
Storage Instructions
Valid for 12 months from date of receipt when stored at -80°C. Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Storage buffer
Shipped at ambient temperature.
Purity
> 95% as determined by Tris-Bis PAGE
target relevance
Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex composed of the IL-7 receptor alpha chain (IL-7Ralpha) and the TSLP receptor (TSLPR, also known as CRLF2).
Protein names
Cytokine receptor-like factor 2 (Thymic stromal lymphopoietin protein receptor) (TSLP receptor)
Protein family
Type I cytokine receptor family, Type 5 subfamily
Mass
38445Da
Function
Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5 (By similarity). Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. {ECO:0000250, ECO:0000269|PubMed:11891057}.
Subellular location
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Tissues
Expressed in all tissues examined including brain, thymus, lung, heart, muscle, stomach, small intestine, liver, kidney, spleen, testis and skin. Highest levels in thymus, liver and testis. {ECO:0000269|PubMed:11891057}.
Structure
Heterodimer of CRLF2 and IL7R.
Domain
The WSXWS motif appears to be necessary for proper protein folding and thereby efficient int
Target Relevance information above includes information from UniProt accession: Q8R4S8
The UniProt Consortium

ELISA with Cynomolgus TSLPR Protein
Immobilized Cynomolgus TSLPR, His Tag at 2µg/ml (100µl/Well) on the plate. Dose response curve for Biotinylated Cynomolgus TSLP, His Tag with the EC50 of 0.12µg/ml determined by ELISA (QC Test).
ELISA with Cynomolgus TSLPR Protein
Immobilized Cynomolgus TSLPR, His Tag at 0.5µg/ml (100µl/Well) on the plate. Dose response curve for Anti-TSLPR Antibody, hFc Tag with the EC50 of 13.3ng/ml determined by ELISA.
HPLC of Cynomolgus TSLPR Protein
The purity of Cynomolgus TSLPR is greater than 95% as determined by SEC-HPLC.
SDS-PAGE gel of Cynomolgus TSLPR Protein
Cynomolgus TSLPR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

Publications

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We haven't added any publications to our database yet.
Published literature highly relevant to the biological target of this product and referencing this antibody or clone are retrieved from PubMed database provided by The United States National Library of Medicine at the National Institutes of Health.

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